Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
Introduction to Urinary System01:13

Introduction to Urinary System

The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-profiled treatment responses in a large hypertension trial: a posthoc analysis of the INSIGHT study.

Journal of hypertension·2026
Same author

Resistant Hypertension Is Not Essential: It Is Primarily Aldosteronism.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

EndoCompass Project: Research Roadmap for Adrenal and Cardiovascular Endocrinology.

Hormone research in paediatrics·2025
Same author

Adrenal Aldosterone Synthase Expression Imaging in Primary Aldosteronism.

The New England journal of medicine·2025
Same author

Voxel-Level Comparison of [<sup>18</sup>F]CETO and [<sup>11</sup>C]MTO for Molecular Imaging of Primary Aldosteronism.

Journal of nuclear medicine technology·2025
Same author

EndoCompass project: research roadmap for adrenal and cardiovascular endocrinology.

European journal of endocrinology·2025

Related Experiment Video

Updated: Jul 15, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Renin: friend or foe?

Morris J Brown1

  • 1Clinical Pharmacology Unit, Addenbrookes Hospital, Cambridge, UK. m.j.brown@cai.cam.ac.uk

Heart (British Cardiac Society)
|May 10, 2007
PubMed
Summary

Therapeutic strategies targeting the renin system are valuable for managing high blood pressure and reducing vascular death. Understanding renin

Area of Science:

  • Biochemistry
  • Physiology
  • Pharmacology

Background:

  • Renin plays a crucial role in blood pressure regulation via vasoconstriction, particularly when sodium levels are low.
  • High blood pressure and vascular death are prevalent in certain populations, making renin modulation a potential therapeutic target.
  • The renin-angiotensin system (RAS) is a key regulator of blood pressure, involving renin, angiotensin II, and their receptors.

Purpose of the Study:

  • To explore the therapeutic value of reducing renin secretion or response in managing hypertension.
  • To investigate whether the benefits of renin-targeted therapies are solely attributable to blood pressure reduction.
  • To elucidate the optimal use of drugs that modulate the renin-angiotensin system.

Main Methods:

  • Blocking the renin-angiotensin system at various points: rate-limiting step (beta-blockade, direct renin inhibition), angiotensin II synthesis, or angiotensin receptors.

More Related Videos

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

Related Experiment Videos

Last Updated: Jul 15, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

  • Measuring renin levels, which are inversely related to sodium load, as a key diagnostic and monitoring tool.
  • Combining natriuresis with blockade of renin activity for comprehensive blood pressure control.

    • Main Results:

    • Therapeutic reductions in renin activity are valuable in populations with prevalent hypertension and vascular death.
    • The precise contribution of blood pressure reduction to the long-term benefits of renin-targeted therapies requires further investigation.
    • Renin measurement is a simple, cost-effective, and stable hormone assay.

    Conclusions:

    • Understanding the biochemistry and physiology of renin is essential for optimizing therapies that modulate this hormone.
    • Combined strategies involving natriuresis and renin activity blockade are key for effective blood pressure management.
    • Targeting the renin-angiotensin system offers a valuable approach to managing hypertension and associated vascular risks.