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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
A new cytotoxic prenylated chalcone from Sophora flavescens
Jae Hyeok Lee1, Nam-In Baek, Sung-Hoon Kim
1Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, Korea.
Archives of Pharmacal Research
|May 11, 2007
Abstract:
We have isolated a new prenylated chalcone from the roots of Sophora flavescens (Leguminosae). We determined that structure of this compound is 7,9,2',4'-tetrahydroxy-8-isopentenyl-5-methoxychalcone (1) on the basis of spectroscopic analysis (1D and 2D NMR data). Compound 1 exhibited potent cytotoxicity against human acute promyelocytic (HL60), mouse lymphocytic (L1210) and human histiocytic (U937) leukemia cells.
