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Updated: Jul 15, 2026

Intravitreal Injections in the Ovine Eye

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

Intravitreal steroids and Eales' disease.

Mohammad Shahid¹, Agha Hassan Feroze, Mazhar Ishaq

¹Department of Ophthalmology, Military Hospital, Rawalpindi.

JPMA. the Journal of the Pakistan Medical Association

|May 11, 2007

Summary

Intravitreal triamcinolone shows promise for treating Eales' disease, a chronic retinal vasculitis. This treatment reduced vascular leakage in a patient, offering a potential new therapy for this difficult-to-manage condition.

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Area of Science:

Ophthalmology
Retinal Vascular Diseases

Background:

Eales' disease is a chronic, idiopathic retinal vasculitis primarily affecting young adult males, prevalent in Saudi Arabia.
Current treatments like oral steroids, panretinal photocoagulation, and vitrectomy have limitations in managing this condition.
Idiopathic retinal vasculitis poses significant challenges in clinical practice due to its chronic and difficult-to-treat nature.

Observation:

A single patient diagnosed with Eales' disease received an intravitreal injection of triamcinolone acetonide.
Pre- and post-operative fluorescein fundus angiography were conducted to assess treatment efficacy.
The study observed a reduction in perivascular leakage of fluorescein dye after the intravitreal injection.

Findings:

Post-operative fluorescein fundus angiography demonstrated a notable decrease in perivascular leakage compared to preoperative imaging.
The findings suggest that intravitreal triamcinolone may effectively reduce vascular leakage in Eales' disease.
This case report supports previous findings from the Indo-Pak subcontinent regarding this treatment approach.

Implications:

Intravitreal triamcinolone presents a potentially effective and promising therapeutic option for managing retinal vasculitis, specifically Eales' disease.
Further research and larger clinical trials are warranted to validate these findings and establish intravitreal triamcinolone as a standard treatment.
This approach could offer a new avenue for patients with Eales' disease who have limited treatment options or have not responded well to conventional therapies.