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Updated: Jul 15, 2026
08:51
Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
Published on: March 1, 2013
Polymeric nano- and microparticle technologies for oral gene delivery
Mayank D Bhavsar1, Mansoor M Amiji
1Doctoral Candidate, Northeastern University, Department of Pharmaceutical Sciences, School of Pharmacy, 110 Mugar Life Sciences Building, Boston, MA 02115, USA.
Expert Opinion on Drug Delivery
|May 11, 2007
Summary
Polymeric nanoparticles offer a promising approach for oral gene therapy, enabling disease treatment and prevention through DNA delivery. This review explores polymer technologies for effective oral gene and DNA vaccine administration.
Area of Science:
- Biotechnology
- Nanotechnology
- Pharmacology
Background:
- Gene therapy involves administering nucleic acid constructs to modify gene expression for disease treatment.
- Oral gene therapy presents potential for treating local diseases like inflammatory bowel disease and for systemic protein delivery.
- Efficient oral DNA vaccine delivery is crucial for disease prevention.
Purpose of the Study:
- To review the challenges and opportunities in developing polymer-based nano- and microparticle technologies for oral gene therapy.
- To discuss the application of these delivery systems for oral DNA administration in therapeutics and vaccination.
Main Methods:
- Focus on synthetic and natural polymers used in formulating nano- and microparticle delivery systems.
- Review of polymer-based technologies for oral administration of gene therapeutics and DNA vaccines.
Main Results:
- Polymeric gene delivery vectors are key to translating gene therapy into clinical practice.
- Nano- and microparticle technologies are being developed for efficient oral gene delivery.
- Various synthetic and natural polymers are utilized for formulating these delivery systems.
Conclusions:
- Polymer-based nano- and microparticle technologies hold significant promise for advancing oral gene therapy.
- These technologies can facilitate oral DNA administration for both therapeutic applications and vaccination purposes.
- Further development is needed to overcome challenges and realize the full potential of oral gene therapy.
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