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Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole
Published on: December 5, 2025
Functional paradigm evolution in microneedle materials: design strategies, performance trade-offs, and translational
1Academy of Military Medical Sciences, Beijing, China.
Expert Opinion on Drug Delivery
|August 11, 2026
Summary
Microneedle (MN) materials are advancing for transdermal drug delivery. Innovations focus on optimizing performance, manufacturability, and safety for clinical translation.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Microneedles (MNs) offer minimally invasive transdermal delivery of therapeutics.
- Material properties are critical for MN performance and efficacy.
- Continuous innovation in MN materials drives the field's evolution.
Purpose of the Study:
- To review and analyze microneedle materials based on functional paradigms.
- To compare material designs, advantages, limitations, and trade-offs.
- To highlight recent advances and challenges in clinical translation.
Main Methods:
- Literature survey of publications from 2020-2026 using Web of Science and PubMed.
- Analysis of MN materials categorized into structural, controlled-release, intelligent integrated, and glassy systems.
- Comparison of representative materials based on design, drug loading, release control, and biocompatibility.
Main Results:
- MN material design is shifting towards translation-oriented optimization.
- Increasing functionality must be balanced with reproducibility, manufacturability, and safety.
- Representative materials show diverse trade-offs between drug loading, release control, and biocompatibility.
Conclusions:
- Future MN material development requires simplified, high-performance systems.
- Predictable responsive release and drug-specific designs are crucial.
- Balancing loading capacity, release precision, and biocompatibility is key for clinical impact.