Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progress in absorption enhancers based on tight junction.

Masuo Kondoh1, Kiyohito Yagi

  • 1Osaka University, Department of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Suita, Osaka 565-0871, Japan. masuo@phs.osaka-u.ac.jp

Expert Opinion on Drug Delivery
|May 11, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting claudins in cancer.

Nature reviews. Drug discovery·2026
Same author

Overview of the Japanese Rapid Introduction Premium as a drug pricing framework to enhance patient access to innovative drugs.

Health economics review·2025
Same author

Claudin 5-binding small molecule transiently opens the blood-brain barrier and safely enhances brain drug delivery.

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

Magnitude of the Digital Placebo Effect and Its Moderators on Generalized Anxiety Symptoms: Systematic Review and Meta-Analysis.

Journal of medical Internet research·2025
Same author

Identification of amino acids essential for angulin-1/3 binding of the tricellular tight junction binder, angubindin-1.

FEBS open bio·2025
Same author

Loss of angulin-1/LSR promotes vasculogenic mimicry and epithelial-mesenchymal transition in breast cancer.

The Journal of biological chemistry·2025

Developing effective oral drug delivery requires understanding intestinal absorption enhancers. Research into tight junction biology and novel strategies is crucial for advancing drug absorption and reducing toxicity.

Area of Science:

  • Pharmacology
  • Cell Biology
  • Drug Delivery

Background:

  • Absorption enhancers aim to improve drug transfer across the intestinal epithelium.
  • Clinical use of enhancers is limited by specificity and toxicity challenges.
  • Emerging drug candidates necessitate advanced oral delivery strategies.

Purpose of the Study:

  • To review the historical development of absorption enhancers.
  • To outline recent cell biology findings on tight junction regulation.
  • To discuss novel absorption enhancer strategies based on new research.

Main Methods:

  • Literature review of absorption enhancer development.
  • Analysis of cell biology research on paracellular transport.
  • Synthesis of new absorption enhancer approaches.

Related Experiment Videos

Main Results:

  • Few absorption enhancers are currently in clinical use.
  • Understanding paracellular mechanisms is key to enhancer development.
  • Advances in cell biology offer new strategies for absorption enhancement.

Conclusions:

  • Novel absorption enhancers are needed for new drug classes.
  • Targeting tight junction regulation is a promising strategy.
  • Further research in cell biology will drive innovation in drug delivery.