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Circulating oncoproteins HER2/neu, EGFR and CAIX (MN) as novel cancer biomarkers

Walter P Carney1

  • 1Oncogene Science, Siemens Medical Solutions Diagnostics, Cambridge, MA 02142, USA. walter.carney@siemens.com

Expert Review of Molecular Diagnostics
|May 11, 2007
PubMed

Insights

Targeted cancer therapies require specific biomarkers for patient selection and monitoring. Circulating oncoproteins like HER2/neu, EGFR, and CAIX, detected via enzyme-linked immunosorbent assays, aid in personalized treatment strategies for improved outcomes.

Area of Science:

  • Oncology
  • Biomarker Discovery
  • Translational Medicine

Background:

  • Targeted therapies for HER2/neu-positive and EGFR-positive tumors are established.
  • Rencarex targets carbonic anhydrase IX (CAIX) in renal cell carcinoma.
  • The development of targeted therapies necessitates companion diagnostics.

Purpose of the Study:

  • To review clinical research on enzyme-linked immunosorbent assays for circulating oncoproteins HER2/neu, EGFR, and CAIX.
  • To explore the utility of these biomarkers in patient selection, monitoring, and management for targeted therapies.
  • To highlight the importance of biomarker testing in personalized cancer treatment.

Main Methods:

  • Review of clinical studies utilizing enzyme-linked immunosorbent assays (ELISAs).
  • Focus on assays detecting circulating oncoproteins: HER2/neu, EGFR, and CAIX.
  • Analysis of biomarker data in the context of targeted therapy selection and monitoring.

Main Results:

  • Circulating oncoproteins (HER2/neu, EGFR, CAIX) can be detected using specific ELISAs.
  • These biomarkers show potential for patient selection and monitoring in targeted cancer therapy.
  • Serum HER2/neu may identify patients with progressing HER2/neu-positive disease.

Conclusions:

  • Biomarker tests are crucial for selecting the right targeted therapy for individual patients.
  • Specific biomarker panels will be essential for guiding treatment decisions and monitoring efficacy.
  • Circulating biomarkers facilitate personalized medicine by matching patients to appropriate targeted treatments.

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