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Related Experiment Video

Updated: May 15, 2026

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology
09:45

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Microfluidics and circulating tumor cells.

Yi Dong1, Alison M Skelley, Keith D Merdek

  • 1On-Q-ity Inc., Waltham, Massachusetts 02451, USA.

The Journal of Molecular Diagnostics : JMD
|December 26, 2012
PubMed
Summary
This summary is machine-generated.

Circulating tumor cells (CTCs) are rare cancer cells in blood. Microfluidic devices offer a promising approach for isolating and studying these critical cells to understand cancer metastasis.

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Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

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Last Updated: May 15, 2026

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology
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Published on: November 14, 2025

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
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Published on: October 13, 2023

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research
07:47

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

Area of Science:

  • Oncology
  • Biomedical Engineering
  • Cell Biology

Background:

  • Circulating tumor cells (CTCs) are key drivers of cancer metastasis and patient mortality.
  • Detecting and analyzing CTCs aids in understanding cancer progression and developing treatments.
  • CTCs are rare and heterogeneous, making their isolation from blood extremely challenging.

Purpose of the Study:

  • To review microfluidic technologies for the enrichment and isolation of circulating tumor cells (CTCs).
  • To highlight the potential of microfluidics in advancing CTC analysis for cancer research and clinical applications.

Main Methods:

  • Review of microfluidic devices and techniques for CTC capture.
  • Analysis of methods based on physical properties (size, deformability) and biological characteristics (surface markers).
  • Discussion of challenges and advancements in microfluidic CTC isolation.

Main Results:

  • Microfluidics enables efficient enrichment of rare CTCs from complex blood samples.
  • Various microfluidic strategies demonstrate high capture efficiency and purity of CTCs.
  • These methods facilitate downstream molecular and functional characterization of CTCs.

Conclusions:

  • Microfluidic approaches represent a significant advancement in CTC isolation technology.
  • Improved CTC isolation through microfluidics can enhance cancer monitoring and therapeutic strategies.
  • Further development of microfluidic devices is crucial for routine clinical use in oncology.