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Related Experiment Videos

Preterm labour. Cervical function and prematurity.

Jane E Norman1

  • 1University of Glasgow, Division of Developmental Medicine, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK. j.e.norman@clinmed.gla.ac.uk

Best Practice & Research. Clinical Obstetrics & Gynaecology
|May 11, 2007
PubMed
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The cervix is crucial for maintaining pregnancy and enabling delivery. Cervical length and fetal fibronectin may predict preterm birth, while cervical cerclage offers some protection against preterm delivery in singleton pregnancies.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Reproductive Biology

Background:

  • The cervix plays a vital role in maintaining pregnancy and facilitating childbirth.
  • Cervical structural abnormalities are linked to increased preterm birth risk.
  • The impact of cervical infection on preterm birth remains uncertain.

Purpose of the Study:

  • To review the role of the cervix in the prediction and prevention of spontaneous preterm birth.
  • To evaluate diagnostic markers and interventions for preterm delivery.
  • To assess the efficacy and risks of cervical cerclage.

Main Methods:

  • Review of existing literature on cervical function, preterm birth prediction, and interventions.
  • Analysis of ultrasound assessment of cervical length.

Related Experiment Videos

  • Examination of fetal fibronectin testing in cervico-vaginal secretions.
  • Evaluation of data on cervical cerclage outcomes.

    • Main Results:

    • Shortened cervical length and elevated fetal fibronectin levels are associated with higher preterm delivery risk.
    • Cervical cerclage reduces preterm birth by 25% in singleton pregnancies.
    • No demonstrated reduction in neonatal mortality or morbidity with cerclage; maternal infection risk is a concern.

    Conclusions:

    • Cervical assessment (length, fibronectin) shows potential for preterm birth prediction.
    • Cervical cerclage effectiveness is debated due to risks and lack of neonatal benefit.
    • Further research is needed to clarify the cervix's role in preventing spontaneous preterm birth.