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Cerebrospinal fluid concentration of cyclic AMP in cerebrovascular diseases
Insights
Cerebrospinal fluid cyclic adenosine 3
Area of Science:
- Neurology
- Biochemistry
Background:
- Cerebrovascular diseases impact brain cell function.
- Cyclic adenosine 3',5'-monophosphate (cAMP) is a key intracellular second messenger.
- Investigating CSF biomarkers can aid in understanding cerebrovascular disease pathology.
Purpose of the Study:
- To measure cyclic adenosine 3',5'-monophosphate (cAMP) levels and enzyme activities in cerebrospinal fluid (CSF) of patients with cerebrovascular diseases.
- To correlate CSF cAMP concentrations with disease type, duration, and patient hypertension.
- To explore the potential of CSF cAMP as a biomarker for cerebral cell damage and sympathetic activity.
Main Methods:
- Analysis of cerebrospinal fluid (CSF) from 38 patients with various cerebrovascular conditions.
- Measurement of cyclic adenosine 3',5'-monophosphate (cAMP) concentrations.
- Assay of specific enzyme activities in CSF.
- Comparison of patient groups with control subjects (cephalagia without pathology).
Main Results:
- CSF cAMP levels were significantly elevated in acute carotid area cerebral infarction (less than 14 days).
- Elevated CSF cAMP showed a trend in cerebral hemorrhage but was normal in subarachnoid hemorrhage, TIA, syncope, and chronic infarction.
- CSF enzyme activities increased significantly only in hemorrhagic disorders.
- Hypertensive patients exhibited higher CSF cAMP levels, suggesting a correlation with blood pressure and possibly sympathetic activity.
Conclusions:
- CSF cAMP concentration may indicate the extent and timing of cerebral cell destruction in cerebrovascular diseases.
- CSF cAMP levels correlate with patient hypertension, potentially reflecting increased sympathetic nervous system activity.
- CSF cAMP and enzyme activity patterns differ based on cerebrovascular disease type and chronicity.
Abstract:
Concentration of cyclic adenosine 3',5'-monophosphate (cAMP) and activities of some enzymes were measured in cerebrospinal fluid (CSF) from 38 patients with various cerebrovascular diseases. Cerebral infarction of the carotid area (less than 14 days after the attack) revealed a significant increase in CSF cAMP level in comparison to a transient ischemic attack (TIA) and cephalagia without any pathological findings (control group). A trend towards elevated values was observed also in cerebral hemorrhage, whereas the CSF cAMP concentrations in subarachnoid hemorrhage, TIA, syncope, and cerebral infarction of at least 2 months of duration were in the range of control values. A significant rise in CSF enzyme activities was observed only in hemorrhagic disorders. Hypertensive patients with TIA showed significantly higher CSF cAMP values than normotensive ones. A similar positive correlation between blood pressure and CSF aAMP concentrations was found also in subarachnoid hemorrhage and syncope groups. On the basis of the present results it is suggested that in cerebrovascular diseases CSF cAMP concentration reflects the size and the time of the destruction of cerebral cells, and correlates with hypertension of the patient possibly indicating an increased sympathetic activity.