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Related Experiment Video

Updated: Jul 15, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Treating actinic keratoses with imiquimod.

Anthony Dixon¹

¹Skin Alert Skin Cancer Clinics and Skincanceronly, Belmont, Victoria, Australia. anthony@skincanceronly.com

Australian Family Physician

|May 12, 2007

Summary

Cryotherapy for extensive actinic damage, including squamous cell carcinomas (SCCs) and actinic keratoses (AKs), is uncomfortable and inefficient for Mr KC. New lesions develop faster than they can be treated, limiting treatment success.

Area of Science:

Dermatology
Oncology

Background:

Actinic damage presents a significant challenge in dermatology, often leading to precancerous and cancerous skin lesions.
Squamous cell carcinomas (SCCs) and actinic keratoses (AKs) are common consequences of prolonged sun exposure.

Observation:

Mr KC, a 61-year-old male, exhibits widespread actinic damage on his face and forehead.
He has undergone years of cryotherapy for SCCs and AKs with suboptimal outcomes.
The treatment is highly uncomfortable, restricting the number of lesions treated per session and resulting in a slower treatment rate than lesion development.

Findings:

Cryotherapy provides temporary resolution of actinic lesions but is poorly tolerated due to discomfort.
The patient's rate of lesion development outpaces the capacity for cryotherapy treatment.

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Last Updated: Jul 15, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Limited success is attributed to the patient's discomfort and the rapid recurrence/formation of new lesions.

Implications:

Current cryotherapy protocols may not be suitable for patients with extensive, rapidly developing actinic damage.
Alternative or adjunctive treatments for SCCs and AKs warrant investigation for improved patient tolerance and efficacy.
Effective management strategies are needed to address the high burden of actinic damage and associated skin cancers.