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[Factors determining hyperhomocysteinemia in the chronic phase of strokes]

F J Carod-Artal1, S V Nunes, A P Vargas

  • 1Service de Neurologiá, Hospital Sarah Centro, Brasilia DF, Brasil. javier@sarah.br

Revista De Neurologia
|May 12, 2007
PubMed

Insights

Hyperhomocysteinemia, a condition linked to ischemic stroke, is influenced by both genetic factors like the MTHFR gene mutation and environmental factors such as age, smoking, and sex. These factors significantly impact homocysteine levels in stroke patients.

Area of Science:

  • Neurology
  • Genetics
  • Cardiovascular Research

Context:

  • Ischemic stroke is a significant health concern with multiple contributing factors.
  • Hyperhomocysteinemia has been associated with an increased risk of ischemic stroke.
  • Understanding the determinants of hyperhomocysteinemia is crucial for stroke prevention and management.

Purpose:

  • To investigate the primary factors influencing hyperhomocysteinemia in patients during the chronic phase of ischemic stroke.
  • To analyze the relationship between homocysteine levels, MTHFR gene mutations, and various risk factors in stroke survivors.

Summary:

  • A study of 280 ischemic stroke patients revealed that 44.3% had elevated homocysteine (Hc) levels.
  • Hyperhomocysteinemia was more prevalent in patients over 45 years old.
  • Key determinants identified through regression analysis included age, MTHFR gene mutation (C677T), smoking, and male sex.

Impact:

  • Identifies specific genetic and environmental factors contributing to hyperhomocysteinemia in stroke patients.
  • Provides insights into the complex interplay of factors affecting homocysteine levels post-stroke.
  • Informs potential therapeutic strategies targeting homocysteine levels for stroke risk reduction.
Abstract

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