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Related Experiment Videos

Trimethoprim-sulfamethoxazole.

F R Cockerill1, R S Edson

  • 1Division of Infectious Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.

Mayo Clinic Proceedings
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

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Trimethoprim-sulfamethoxazole effectively treats various bacterial infections, including genitourinary, respiratory, and gastrointestinal issues. Dosage adjustments are necessary for patients with impaired kidney function, specifically a creatinine clearance below 30 ml/min.

Area of Science:

  • Pharmacology
  • Microbiology
  • Infectious Diseases

Background:

  • Trimethoprim-sulfamethoxazole is a widely used antimicrobial agent.
  • It exhibits in vitro activity against a broad spectrum of bacteria.
  • Clinical applications include prophylaxis and treatment of various infections.

Purpose of the Study:

  • To review the clinical utility and pharmacokinetic properties of trimethoprim-sulfamethoxazole.
  • To highlight its role in treating specific infections like Nocardia asteroides and Pneumocystis carinii pneumonia.
  • To emphasize the importance of dosage adjustment in renal impairment.

Main Methods:

  • Literature review of clinical studies and pharmacokinetic data.
  • Analysis of in vitro antimicrobial activity.

Related Experiment Videos

  • Evaluation of clinical efficacy and safety profiles.

    • Main Results:

    • Demonstrated efficacy against gram-positive and gram-negative bacteria.
    • Established role in treating genitourinary, respiratory, and gastrointestinal infections.
    • Identified as a primary treatment for Nocardia asteroides and Pneumocystis carinii pneumonia.
    • Generally well-tolerated, with specific considerations for patients with AIDS.
    • Excretion primarily via urine, necessitating dosage adjustment for renal insufficiency (creatinine clearance < 30 ml/min).

    Conclusions:

    • Trimethoprim-sulfamethoxazole is a valuable antimicrobial for diverse infections.
    • Its efficacy is well-documented for specific conditions like Nocardia and Pneumocystis infections.
    • Renal function monitoring and dose adjustment are critical for safe and effective use.