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Non-B DNA conformations, mutagenesis and disease

Robert D Wells1

  • 1Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Texas Medical Center, 2121 West Holcombe Boulevard, Houston, TX 77030-3303, USA. rwells@ibt.tamhsc.edu

Trends in Biochemical Sciences
|May 12, 2007
PubMed
Summary

Simple repeating DNA sequences forming non-B DNA structures are mutagenic. These DNA conformations, not the sequence itself, cause genetic disorders and diseases.

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