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Related Concept Videos

GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
Two...
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The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
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Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers

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The Parathyroid Glands00:59

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Related Experiment Video

Updated: Jul 15, 2026

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources
05:18

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Published on: October 6, 2023

The PPAR resource page.

John P Vanden Heuvel1

  • 1Department of Veterinary and Biomedical Sciences Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA. jpv2@psu.edu

Biochimica Et Biophysica Acta
|May 12, 2007
PubMed
Summary

Peroxisome proliferator-activated receptors (PPARs) are crucial nuclear receptors regulating metabolism and inflammation. The PPAR Resource Page offers scientists vital data and tools for researching these proteins and their role in chronic diseases.

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Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader

Published on: May 24, 2024

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors controlling cellular and metabolic processes.
  • Three isotypes (PPARalpha, PPARbeta/delta, PPARgamma) exist in mammals, with distinct tissue distribution and functions.
  • PPARs influence energy homeostasis and inflammatory responses, and their activity is modulated by drugs like fibrates and thiazolidinediones.

Purpose of the Study:

  • To provide a comprehensive resource for scientists studying PPARs.
  • To disseminate information on PPAR biology, including sequences, alignments, and response elements.
  • To offer bioinformatics support and links to related databases and research communities.

Main Methods:

  • Website development and maintenance (PPAR Resource Page).
  • Data aggregation from public databases.
  • Integration with the Nuclear Receptor Resource (NRR) for shared tools.

Main Results:

  • The PPAR Resource Page provides access to cDNA sequences, protein alignments, PPREs, and sources for cDNAs, proteins, and antibodies.
  • Recent additions include bioinformatics tools for gene expression microarray and pathway analysis.
  • The website receives over 300 unique visits weekly, indicating its utility for researchers.

Conclusions:

  • The PPAR Resource Page is a valuable and widely used tool for researchers investigating PPARs.
  • Understanding PPAR biology and modulators is critical for addressing chronic diseases like diabetes, obesity, and atherosclerosis.
  • Continued development and integration with resources like NRR enhance its value to the scientific community.