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Related Experiment Videos

Migraine aura.

F Michael Cutrer1, Karina Huerter

  • 1Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. cutrer.michael@mayo.edu

The Neurologist
|May 15, 2007
PubMed
Summary
This summary is machine-generated.

Migraine aura, characterized by transient neurological symptoms, may stem from cortical spreading depression (CSD). Understanding this mechanism could lead to new migraine prevention therapies.

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Area of Science:

  • Neurology
  • Neuroscience
  • Headache Medicine

Background:

  • Migraine aura involves transient focal neurological symptoms like visual, sensory, or language disturbances.
  • Approximately 11.9 million people in the US experience migraine with aura.
  • The International Headache Society recognizes three typical aura types.

Purpose of the Study:

  • To explore the underlying mechanisms of migraine aura.
  • To investigate the potential link between cortical spreading depression (CSD) and typical auras.
  • To examine how cortical processing alterations may increase vulnerability to CSD-like events in migraineurs.

Main Methods:

  • Review of existing human subject investigations and recent research findings.
  • Analysis of evidence suggesting CSD-like phenomena as the basis for typical auras.

Related Experiment Videos

  • Examination of studies on altered cortical reactivity in migraineurs experiencing aura.

    • Main Results:

    • Increasing evidence suggests typical migraine auras are manifestations of a cortical spreading depression (CSD)-like phenomenon.
    • Migraineurs with aura may exhibit altered cortical reactivity, increasing susceptibility to CSD-like events.
    • Cerebral cortical events are hypothesized to activate trigeminal nociceptive neurons and affect cranial vasculature.

    Conclusions:

    • Understanding the mechanisms of migraine aura, potentially involving CSD, is crucial.
    • Further research into cortical events and their link to trigeminal pathways may reveal new therapeutic targets.
    • This knowledge could pave the way for therapies aimed at preventing migraine onset.