Constituents of Cissus quadrangularis.

Area of Science:

• Phytochemistry
• Natural Product Chemistry
• Ethnobotany

Background:

• Cissus quadrangularis Linn. is a plant with a history of traditional medicinal use.
• The phytochemical profile of Cissus quadrangularis Linn. has not been fully elucidated, particularly regarding iridoid compounds.
• Understanding the chemical constituents of medicinal plants is crucial for validating their therapeutic potential.

Purpose of the Study:

• To isolate and identify chemical constituents from Cissus quadrangularis Linn.
• To characterize novel compounds and report the first occurrence of specific chemical classes in this plant.
• To contribute to the phytochemical database of Cissus quadrangularis Linn.

Main Methods:

• Phytochemical investigation involving extraction and isolation techniques.
• Structure elucidation using spectroscopic methods (e.g., NMR, MS).
• Comparison of isolated compounds with existing literature data.

Main Results:

• Isolation of two new iridoids: 6-O-[2,3-dimethoxy]-trans-cinnamoyl catalpol (1) and 6-O-meta-methoxy-benzoyl catalpol (2).
• Identification of known compounds: picroside 1 (3), quadrangularin A (4), pallidol (5), quercitin (6), quercitrin (7), beta-sitosterol (8), and beta-sitosterol glycoside (9).
• First-time reporting of compounds 3 and 7 from Cissus quadrangularis Linn. and the first-ever discovery of iridoids in this plant.

Conclusions:

• The phytochemical analysis of Cissus quadrangularis Linn. has revealed a diverse array of compounds, including novel iridoids.
• The presence of iridoids in Cissus quadrangularis Linn. is reported for the first time.
• This study expands the understanding of the chemical constituents of Cissus quadrangularis Linn. and provides a basis for further pharmacological investigations.