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Related Experiment Videos

Enterovirus in arteriosclerosis: a pilot study.

Cécile Schanen1, Dorsaf Nasri, Thomas Bourlet

  • 1Laboratory of Bacteriology-Virology, GIMAP, Faculty of Medicine of Saint-Etienne, France.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|May 15, 2007
PubMed
Summary
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Enterovirus genomes were detected in atherosclerotic plaques, suggesting a potential role for this virus in advanced arteriosclerosis. Further research is needed to confirm the clinical significance of this association.

Area of Science:

  • Infectious disease
  • Cardiovascular pathology
  • Molecular biology

Background:

  • Pathogens are implicated in atherosclerotic lesion development.
  • Enteroviruses are suspected contributors to atherosclerosis.
  • Experimental and epidemiological data support a role for enteroviruses.

Purpose of the Study:

  • To determine the prevalence of enterovirus genome in atherosclerotic plaques.
  • To compare enterovirus prevalence with Chlamydia pneumoniae, human cytomegalovirus (hCMV), and herpes simplex virus.

Main Methods:

  • Pilot study involving 18 patients undergoing artery resection.
  • Polymerase Chain Reaction (PCR) used to detect pathogen genomes in five artery samples per patient.
  • Human aldolase A gene amplification used to assess DNA extraction quality.

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Main Results:

  • Infectious agent genomes detected in 38.9% of patients (7/18).
  • Enterovirus genome found in 22.2% of patients (4/18), with one also positive for hCMV.
  • PCR products confirmed by sequencing; only one aliquot per patient tested positive.

Conclusions:

  • Enterovirus genome is frequently detected in advanced arteriosclerotic lesions.
  • These findings suggest a potential association between enterovirus and atherosclerosis.
  • Further studies are required to elucidate the clinical significance of this association.