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Updated: Jul 15, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
The missing care bundle: antibiotic prescribing in hospitals.
Fiona J Cooke1, Alison H Holmes
1Department of Infectious Diseases and Immunology, Hammersmith Hospitals NHS Trust, Imperial College, Du Cane Road, London W12 0HS, UK. fiona@sanger.ac.uk
Care bundles improve patient care by standardizing treatments. This study proposes a new care bundle focused on antibiotic prescribing to combat rising infections and antibiotic resistance.
Area of Science:
- Healthcare quality improvement
- Infectious disease management
- Clinical process optimization
Background:
- Care bundles systematically improve and monitor clinical care delivery for specific conditions.
- This approach has proven effective in critical care and reducing hospital-acquired infections (HAIs).
- Existing initiatives focus on HAIs like MRSA but overlook a crucial element.
Purpose of the Study:
- To propose the application of care bundles to optimize antibiotic prescribing processes.
- To address the rising incidence of Clostridium difficile infections.
- To combat antibiotic resistance and enhance overall patient care.
Main Methods:
- Review of existing care bundle applications in healthcare settings.
- Analysis of current strategies for reducing healthcare-associated infections (HAIs).
- Identification of a gap in current interventions related to antibiotic prescribing.
Main Results:
- Care bundles are effective in standardizing care and improving patient outcomes.
- A significant gap exists in systematic approaches to antibiotic prescribing.
- The proposed intervention addresses critical issues like Clostridium difficile and antibiotic resistance.
Conclusions:
- A care bundle approach for antibiotic prescribing is timely and necessary.
- Implementing this intervention can significantly improve patient care and combat antimicrobial resistance.
- This systematic approach ensures consistent delivery of best practices in antibiotic use.
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