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Updated: Jul 15, 2026
09:38
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
[Platelets cytokines and their effects on platelet transfusion]
F Cognasse1, J C Osselaer, O Garraud
1EFS Auvergne-Loire, and GIMAP-EA3064, faculté de médecine, université de Saint-Etienne, 15 rue Ambroise-Paré, 42023 Saint-Etienne cedex 2, France.
Summary
Platelets, beyond hemostasis, modulate immunity through released factors like soluble CD40-Ligand (sCD40L). Stored platelet transfusions may impact immune cell function and cause reactions, with pathogen inactivators influencing cytokine release.
Area of Science:
- Immunology
- Hematology
- Transfusion Medicine
Background:
- Platelets are increasingly recognized for roles beyond hemostasis, including immune modulation.
- Platelets release various cytokines and chemokines, such as soluble CD40-Ligand (sCD40L), which influence innate and adaptive immunity.
- Transfusion of platelet concentrates introduces a significant load of these immunomodulatory factors into recipients.
Purpose of the Study:
- To review the role of platelet secretory products in modulating immune cell parameters.
- To summarize data on cytokines/chemokines released by stored platelets.
- To investigate the involvement of the CD40/CD40L pathway in post-transfusion reactions and the impact of pathogen inactivators.
Main Methods:
- Literature review of studies on platelet immunomodulation and stored platelet products.
- Analysis of data concerning cytokines and chemokines released by platelets during storage.
- Examination of research on the CD40/CD40L system in transfusion contexts.
- Review of recent findings on pathogen inactivators' effects on platelet cytokine release.
Main Results:
- Platelet-derived factors, including sCD40L, significantly impact immune cells like T cells, B cells, monocytes, macrophages, and dendritic cells.
- Stored platelets release substantial amounts of cytokines and chemokines, potentially altering recipient immune functions.
- The CD40/CD40L axis is implicated in post-transfusion reactions.
- Pathogen inactivation methods can affect the release or docking of cytokines/chemokines from platelets.
Conclusions:
- Platelet transfusion involves the infusion of potent immunomodulatory mediators that can alter recipient immunity.
- Understanding stored platelet secretomes is crucial for managing transfusion-related immune effects.
- The CD40/CD40L pathway is a key area of interest for adverse post-transfusion events.
- Further research is needed on pathogen inactivation strategies and their impact on platelet function and immunomodulation.
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