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Deriving clinical prediction rules from stroke outcome research
1Department of Neurology, University of Illinois, Chicago 60612.
Background And Purpose:
Our purpose was to determine whether clinical prediction rules could be derived from current stroke outcome research.
Summary Of Report:
We reviewed 92 articles on stroke outcome research to determine their suitability for implementation as a clinical prediction rule. Methodological problems in many of these studies made implementation of their results as a clinical prediction rule difficult.
Conclusions:
Implementation of stroke outcome research as clinical prediction rules would be facilitated by description of patient population demographics; precise definitions of predictor and outcome measures; stratification of patients by stroke mechanism; use of adequate patient sample sizes; and description of the mathematical methods used, including coding schemes, cutpoints, beta coefficients, constant terms, and a priori probabilities.