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Updated: Jul 15, 2026

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA
Published on: October 1, 2017
Dynamics of DNA tumbling in shear to rotational mixed flows: pathways and periods
Joo Sung Lee1, Eric S G Shaqfeh, Susan J Muller
1Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA.
Abstract:
The tumbling dynamics of DNA have been examined via experiments and Brownian dynamics (BD) simulations in mixed flows that vary from pure shear to pure rotation. In shear, tumbling pathways and periods agree well with earlier studies; in rotation-dominated flows, a new tumbling pathway is identified and experimentally observed. Based on these results, we have developed robust scaling laws for DNA tumbling in both shear and rotational flows and have found a critical flow-type parameter for transition from the shearlike flow regime to the rotation-dominated one.
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