Related Experiment Video
Updated: Jul 14, 2026

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
Published on: June 2, 2022
5-HT and the brain-gut axis: opportunities for pharmacologic intervention
Abstract:
Interactions between the enteric nervous system of the gut and the brain occur bidirectionally over sympathetic and parasympathetic pathways. Coordinated actions of the central, autonomic and enteric nervous systems modulate intestinal motor, sensory and secretory activities by neuromodulators, including 5-HT, noradrenaline and dopamine. 5-HT is an important signaling molecule in the brain-gut axis and the 5-HT released from enterochromaffin cells modulates peristaltic, secretory, vasodilatory, vagal and nociceptive reflexes. Irritable bowel syndrome is associated with altered motility, secretion and sensation; enteric 5-HT signaling may be defective in this disorder. In this editorial, recent data are reviewed and the potential for the development of pharmacologic intervention is assessed.
Related Concept Videos
Gut-Brain Axis
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Physiology of Enteric Nervous System and Gut Health
Gastrointestinal Motility Disorders
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists
