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Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay

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Current concepts in normal and defective angiogenesis: implications for systemic sclerosis.

Mary Jo Mulligan-Kehoe¹, Michael Simons

¹Section of Cardiology, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA.

Current Rheumatology Reports

|May 16, 2007

Summary

Systemic sclerosis involves vascular issues, with early exaggerated blood vessel growth later failing. This review explores the angiogenic imbalance in systemic sclerosis, impacting wound healing and fibrosis.

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Last Updated: Jul 14, 2026

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Published on: November 23, 2014

Area of Science:

Vascular Biology
Rheumatology
Pathophysiology

Background:

Vascular abnormalities are a key feature of systemic sclerosis.
The mechanisms initiating vascular injury and impairing repair in this condition remain unclear.
Early systemic sclerosis shows excessive blood vessel formation (angiogenesis).

Purpose of the Study:

To review current knowledge on the angiogenic imbalance in systemic sclerosis.
To understand the transition from exaggerated angiogenesis to impaired healing.

Main Methods:

Literature review of studies on vascular aspects of systemic sclerosis.
Analysis of research on angiogenesis and fibrosis in the disease context.

Main Results:

Systemic sclerosis exhibits an initial hyper-angiogenic phase.
This is followed by impaired wound healing and fibrotic processes.
An angiogenic imbalance contributes to the disease's vascular pathology.

Conclusions:

The angiogenic imbalance is central to systemic sclerosis vascular complications.
Understanding these mechanisms is crucial for developing targeted therapies.
Further research is needed to elucidate the precise molecular pathways involved.