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Related Concept Videos

Fixation and Sectioning01:03

Fixation and Sectioning

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Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
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Histology of the Small Intestine01:27

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The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
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Histology of the Large Intestine01:26

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The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. Each layer performs a distinct role in facilitating the smooth functioning of the large intestine.
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The stomach comprises several layers that work together to facilitate digestion and protect the organ. The outermost layer is called the serosa, which provides support and protection to the stomach. The muscularis externa layer is responsible for the mechanical breakdown of food by contracting and moving the stomach. The submucosa layer, located beneath the muscularis externa, contains connective tissue, blood vessels, nerves, and glands that secrete mucus and other substances essential for...
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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Related Experiment Video

Updated: Oct 19, 2025

Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography
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Virtual histology.

Andreas König1, Volker Klauss

  • 1Department of Medicine, Division of Cardiology, Medizinische Poliklinik-Innenstadt, Ludwig-Maximilians-Universität, Munich, Germany. andreas.koenig@med.uni-muenchen.de

Heart (British Cardiac Society)
|May 16, 2007
PubMed
Summary

Intravascular ultrasound with Virtual Histology (VH IVUS) offers detailed coronary plaque analysis, overcoming angiography limitations. This technology aids in identifying high-risk lesions and improving patient treatment strategies for coronary artery disease.

Area of Science:

  • Cardiovascular Imaging and Diagnostics
  • Interventional Cardiology
  • Atherosclerosis Research

Background:

  • Coronary angiography provides a luminogram of coronary arteries but lacks arterial wall structure detail, limiting atherosclerosis assessment.
  • Adaptive coronary remodeling, including compensatory enlargement, shifts diagnostic focus to non-stenotic lesions.
  • Intravascular ultrasound (IVUS) enables in vivo plaque imaging, revealing discrepancies with angiography.

Purpose of the Study:

  • To explore the utility of IVUS-derived radiofrequency (RF) data spectrum analysis for detailed plaque composition and morphology assessment.
  • To evaluate Virtual Histology IVUS (VH IVUS) for reconstructing coronary tissue maps and identifying high-risk atherosclerotic lesions.
  • To assess the potential of VH IVUS for differentiating lesion types based on histopathology for improved patient stratification.

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Main Methods:

  • Spectrum analysis of IVUS-derived RF data to analyze plaque components (fibrous, fibrofatty, necrotic core, dense calcium).
  • Preliminary in vitro correlation of histological plaque components with specific RF data spectrum analysis.
  • Reconstruction of coronary tissue maps using IVUS-Virtual Histology (VH IVUS) software from RF data.

Main Results:

  • VH IVUS software enables color-coded mapping of different plaque components.
  • VH IVUS demonstrates potential for detecting high-risk coronary lesions.
  • The technique allows differentiation of lesion types based on histopathological information.

Conclusions:

  • VH IVUS provides insights into coronary atherosclerosis beyond traditional angiography.
  • This advanced imaging modality can reveal plaque composition and morphology.
  • In vivo histological analysis using VH IVUS may enhance treatment stratification for coronary artery disease patients.