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Updated: Jul 14, 2026
16:07
Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
Structural-functional relationships of TNF-alpha antagonists: next steps
Frank J Dann1, Alice B Gottlieb, George S Deepe
1Amgen Inc., Thousand Oaks, California 91320-1799, USA.
Summary
Balancing tumor necrosis factor (TNF) blockade for autoimmune diseases with sufficient TNF activity for infection protection is complex. Further research is needed to fully understand TNF blockers
Area of Science:
- Immunology
- Pharmacology
- Autoimmune Diseases
Background:
- Tumor necrosis factor (TNF) plays a dual role in immunity, mediating inflammation in autoimmune diseases while providing protection against infections.
- TNF antagonist therapies are crucial for managing aggressive autoimmune conditions but can impair immune defenses.
Purpose of the Study:
- To explore the complex balance between therapeutic TNF blockade and essential immune functions.
- To investigate the mechanisms by which TNF antagonists modulate or disrupt inflammatory and apoptotic pathways.
- To identify gaps in current understanding of TNF blocker modes of action.
Main Methods:
- Review of existing data on TNF antagonist effects.
- Analysis of the impact on inflammation and apoptosis cascades.
- Highlighting areas requiring further scientific investigation.
Main Results:
- Current understanding of TNF blocker mechanisms is limited.
- The interplay between TNF blockade and immune protection is not fully elucidated.
- Significant knowledge gaps exist regarding the specific effects of different TNF antagonists.
Conclusions:
- Further research is essential to fully comprehend the multifaceted actions of TNF blockers.
- A deeper understanding is needed to optimize the use of TNF antagonists in autoimmune diseases while minimizing infection risks.
- The current data represent only a preliminary understanding of a complex biological system.
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