Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stress and multiple sclerosis.

David C Mohr1

  • 1Dept. of Preventive Medicine, Northwestern University, Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1220, Chicago, IL, 60611, USA. d-mohr@northwestern.edu

Journal of Neurology
|May 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of a mobile-based self-management program on mental health in young adults: a randomized controlled trial.

Frontiers in public health·2026
Same author

Disparities in Initial Usage of Direct-to-Patient Teledermatology: A Retrospective Observational Study.

Telemedicine journal and e-health : the official journal of the American Telemedicine Association·2026
Same author

Leadership Behaviors and Burnout in Healthcare: A Mixed-Methods Study in the Veterans Health Administration.

Journal of healthcare management / American College of Healthcare Executives·2026
Same author

Digital Mental Health Treatments for Depression.

The Psychiatric clinics of North America·2026
Same author

Popular Online Content as a Treatment-as-Usual Control in Digital Mental Health Intervention Trials: Secondary Analysis of Two Online Randomized Controlled Trials With Repeated Measures.

JMIR mental health·2026
Same author

Haemoglobin A1c Time-In-Range and Mortality in Adults With Diabetes.

Endocrinology, diabetes & metabolism·2026
Same journal

Movement disorders in GLUT1 deficiency syndrome: a systematic review of the literature.

Journal of neurology·2026
Same journal

Detailed clinical characteristics of musical hallucinations in 81 patients.

Journal of neurology·2026
Same journal

The dual role of mTOR in multiple sclerosis pathophysiology: a systematic review.

Journal of neurology·2026
Same journal

Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.

Journal of neurology·2026
Same journal

Spontaneous intracranial hypotension due to pelvic cerebrospinal fluid leak.

Journal of neurology·2026
Same journal

Morbidity and medication use preceding a diagnosis of late-onset Alzheimer's disease: a Danish nationwide study.

Journal of neurology·2026
See all related articles

Stressful life events may worsen multiple sclerosis (MS) relapses. Psychological, social, and biological factors, like glucocorticoid resistance, may influence this link, but stress alone is unlikely to cause MS exacerbation.

Area of Science:

  • Neuroimmunology
  • Psychoneuroimmunology
  • Epidemiology of Multiple Sclerosis

Background:

  • Growing evidence links stressful life events to multiple sclerosis (MS) exacerbations.
  • The interplay between stress and MS relapses involves psychological, social, and biological factors.
  • Understanding these factors is crucial for managing MS progression.

Purpose of the Study:

  • To review current findings on the association between stressful life events and MS exacerbation.
  • To explore potential psychological, social, and biological mechanisms mediating this relationship.
  • To discuss the likelihood of a causal link between stress and MS relapses.

Main Methods:

  • Literature review of studies investigating stress and multiple sclerosis exacerbation.

Related Experiment Videos

  • Analysis of psychological factors (depression, coping, attributions) and social factors (support).
  • Examination of potential biological mechanisms, including glucocorticoid resistance in immune cells.

    • Main Results:

    • Psychological factors like depression, negative attributions, poor coping, and low social support are implicated in worsening the stress-exacerbation relationship.
    • Glucocorticoid resistance in immune cells is proposed as a potential biological pathway.
    • No definitive causal relationship between stressful events and MS exacerbation has been established.

    Conclusions:

    • Stress is likely one contributing factor among many influencing the risk of multiple sclerosis exacerbation.
    • A purely causal relationship where stress alone triggers exacerbation is improbable.
    • Further research is needed to elucidate the complex interplay between stress and MS pathophysiology.