Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.8K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.8K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

5.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.5K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

1.2K
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
1.2K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

15.0K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
15.0K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

6.0K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.0K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

1.4K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Traditional wisdom unveiled: an ethnobotanical exploration of medicinal bath plants for postpartum and infant healthcare among the Hakka people in Guangdong, China.

BMC complementary medicine and therapies·2026
Same author

The prognostic value of different HPV infection statuses in cervical cancer.

Scientific reports·2026
Same author

Cascaded microfiber interferometer-fiber Bragg grating sensor for decoupled strain and temperature measurement.

Applied optics·2026
Same author

Spatiochemical Segregation in Porous Lithium-Metal Interphases.

Journal of the American Chemical Society·2026
Same author

Development and external validation of a machine learning-based Cox model for predicting in-hospital survival in classic heatstroke: a multicenter retrospective study.

Scientific reports·2026
Same author

Assessment of malignant risk in thyroid nodules classified as category 4 and above against a background of Hashimoto's thyroiditis.

Gland surgery·2026

Related Experiment Video

Updated: Mar 31, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.1K

Haemoglobin A1c Time-In-Range and Mortality in Adults With Diabetes.

Paul R Conlin1,2, Julia C Prentice1,3, David C Mohr4,5

  • 1VA Boston Healthcare System, Boston, Massachusetts, USA.

Endocrinology, Diabetes & Metabolism
|March 29, 2026
PubMed
Summary

Glycemic variability, measured by A1c time in range, is linked to diabetes mortality. Reduced A1c stability and increased time below target ranges significantly increase mortality risk in adults with diabetes.

Keywords:
haemoglobin A1chaemoglobin A1c variabilitymortality

More Related Videos

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

773
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.5K

Related Experiment Videos

Last Updated: Mar 31, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.1K
Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

773
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.5K

Area of Science:

  • Endocrinology
  • Metabolic Health
  • Clinical Research

Background:

  • Glycemic variability is a known risk factor for diabetes complications.
  • A1c stability is a novel metric for assessing glycemic control.
  • Understanding A1c stability's impact on mortality is crucial for diabetes management.

Purpose of the Study:

  • To evaluate the association between A1c time in range and mortality in adults with diabetes.
  • To investigate the impact of glycemic variability on long-term health outcomes.
  • To explore the clinical significance of A1c stability as a predictor of mortality.

Main Methods:

  • Retrospective cohort study of 84,229 adults with type 1 and type 2 diabetes (2004-2018).
  • Calculation of A1c time in range (percentage of time within person-specific target ranges).
  • Utilized adjusted Cox and instrumental variable models to assess mortality risk.

Main Results:

  • Reduced A1c time in range (0%-20%) was associated with increased mortality (HR 1.30).
  • Greater time below target A1c range (≥60%) also showed increased mortality risk (HR 1.35).
  • Associations were consistent across subgroups, with higher risk in older adults (≥60 years).

Conclusions:

  • Decreased A1c time in range and increased time below range are significant risk factors for mortality in diabetic adults.
  • A1c stability within personalized ranges may serve as a critical predictor for major adverse outcomes.
  • This study highlights the importance of monitoring glycemic variability for improved diabetes care and patient outcomes.