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Updated: Jul 14, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Negombins A-I, new chlorinated polyfunctional diterpenoids from the marine sponge Negombata species
Amira Rudi1, Yehuda Benayahu, Yoel Kashman
1School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences and Department of Zoology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.
Abstract:
Nine novel compounds designated negombins A-I (1-9) were isolated, together with latrunculin, from the Tanzanian sponge Negombata sp. The nine are sacculatane type diterpenes, previously only known from liverworts. The structures of the compounds were elucidated by interpretation of MS and 1D and 2D NMR spectra. A possible biogenesis initiated by the naturally rare chloronium ion is suggested, possibly hinting to a guest microorganism as the source of the compounds. Compound 4 is toxic to brine shrimp larvae.
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