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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
Rational design of vector and antibiotic peptides using solid-state NMR
A J Mason1, B Bechinger, A Kichler
1Faculté de Chimie, Université Louis Pasteur/ CNRS LC3-UMR7177, Institut le Bel, Strasbourg, France. jmason@chimie.u-strasbg.fr
Mini Reviews in Medicinal Chemistry
|May 17, 2007
Abstract:
The application of 2H solid-state NMR in determining structure activity relationships and mechanism of action of membrane active peptides is discussed. The enhancement of the disruption of anionic lipids in the membrane by new lead compounds is shown to be a key determinant of both DNA vector and antimicrobial activity.
