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Related Experiment Videos

Eosinophils and asthma.

Elizabeth A Jacobsen1, Sergei I Ochkur, Nancy A Lee

  • 1Division of Pulmonary Medicine, SCJMRB-RESEARCH, Mayo Clinic Arizona, 13400 E. Shea Boulevard, Scottsdale, AZ 85259, USA.

Current Allergy and Asthma Reports
|May 17, 2007
PubMed
Summary
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Eosinophils contribute to asthma pathology and lung dysfunction. These cells play roles in immune regulation and lung remodeling, not just destructive actions, in asthma patients.

Area of Science:

  • Immunology
  • Pulmonology
  • Cell Biology

Background:

  • Eosinophils are implicated in asthma pathogenesis, contributing to airway histopathology and lung dysfunction.
  • Emerging research suggests eosinophils also play roles in immune regulation and lung remodeling in asthma.
  • Their functions extend beyond hypothesized destructive roles to include complex cell-cell interactions.

Purpose of the Study:

  • To review the multifaceted roles of eosinophils in the context of asthma.
  • To highlight eosinophil involvement in airway inflammation and tissue remodeling.
  • To synthesize current understanding of eosinophil functions in asthma.

Main Methods:

  • Literature review of recent studies in mouse models and human asthma patients.
  • Analysis of research on eosinophil recruitment, activation, and mediator release.

Related Experiment Videos

  • Examination of cell-cell interactions involving eosinophils in the lung.

    • Main Results:

    • Eosinophil recruitment and activation are key factors in asthma-related lung changes.
    • Eosinophils release various mediators, including proteins, lipids, reactive oxygen species, cytokines, and growth factors.
    • Eosinophils are involved in chronic T helper 2 inflammation through complex cellular interactions.

    Conclusions:

    • Eosinophils are central players in asthma, contributing to both destructive processes and immune regulation.
    • Understanding eosinophil functions is crucial for developing targeted asthma therapies.
    • Further research into eosinophil-mediated pathways can elucidate asthma pathogenesis.