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[Saliva and plasma levels of carbamazepine have a poor correlation: a pilot study]
Sigrid Mennickent1, Mario Vega, Carmen Gloria Godoy
1Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile. smennick@udec.cl
Unlabelled:
Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect. There is not a good relationship between the dose of the carbamazepine and their effects in humans, but the effects of this drug have been well correlated with its plasma levels.
Aim:
To measure the correlation between plasma and saliva levels of carbamazepine in children with epilepsy.
Material And Methods:
Saliva and plasma levels of carbamazepine were measured by using instrumental planar chromatography in 11 epileptic children aged 8 to 15 years treated with the drug for at least six months.
Results:
The mean saliva/plasma ratio was 0.18+/-0.05 and the mean of carbamazepine concentration in saliva, expressed as a percentage of concentrations in plasma, was 17.97+/-5.40. There was a poor linear correlation (r=0.37) between the concentrations of carbamazepine in both fluids.
Conclusions:
In this group of epileptic children the correlation between saliva and plasma carbamazepine levels was weak.
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