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Association between systemic calcified atherosclerosis and bone density.

J A Hyder1, M A Allison, M H Criqui

  • 1Department of Family and Preventive Medicine, University of California San Diego, 3855 Health Sciences Drive, MC 0817, La Jolla, CA 92093-0817, USA.

Calcified Tissue International
|May 17, 2007
PubMed
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Lower bone mineral density (BMD) is linked to increased arterial calcification in major blood vessels. This suggests a potential connection between bone health and cardiovascular disease risk, warranting further investigation.

Area of Science:

  • Cardiovascular Science
  • Bone Metabolism
  • Vascular Biology

Background:

  • Atherosclerosis and osteoporosis contribute significantly to morbidity and mortality.
  • Shared regulatory mechanisms and histopathology may link these conditions.
  • Traditional cardiovascular disease risk factors show weak associations with calcified atherosclerosis, prompting research into novel predictors.

Purpose of the Study:

  • To investigate the hypothesis of an inverse relationship between lumbar bone mineral density (BMD) and calcified atherosclerosis.
  • To assess the association between BMD and arterial calcification in the carotid, coronary, and iliac arteries, as well as the aorta.

Main Methods:

  • Cross-sectional and prospective study designs have primarily indicated an inverse association between BMD and arterial calcification.

Related Experiment Videos

  • Previous studies on men are equivocal.
  • No prior study has examined BMD in relation to systemic arterial calcification.

    • Main Results:

    • The majority of existing studies demonstrate a significant inverse association between arterial calcium deposits and BMD.
    • Some studies report weak or null relationships, highlighting the need for further research.
    • Limited data exists for men, and systemic arterial calcification has not been previously studied in relation to BMD.

    Conclusions:

    • A significant inverse association between lumbar BMD and arterial atherosclerotic calcium in multiple vascular beds is hypothesized.
    • Understanding this relationship could identify novel predictors for cardiovascular disease events.
    • Further research is needed to clarify the association, particularly in diverse populations and across systemic arterial beds.