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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Easy access to new heterocyclic systems: 1,4-oxazine and substituted 1,4-oxazines
Elise Claveau1, Isabelle Gillaizeau, Jérome Blu
1ICOA, UMR 6005, Université d'Orléans, BP 6759, 45067 Orléans cedex 2, France.
Abstract:
In the course of our investigations on the synthesis of new nitrogen heterocyclic derivatives, we were interested in the synthesis and study of new 1,4-oxazine rings. To this aim, the desired bisvinylphosphate was prepared from N-Boc morpholine-3,5-dione and was then engaged in palladium-catalyzed reactions (reduction, Suzuki, and Stille cross-coupling reactions). The 1,4-oxazine and its corresponding 3,5-disubstituted derivatives were obtained in fair to good yields and were then functionalized under anionic conditions.
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