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Cilia and developmental signaling.

Jonathan T Eggenschwiler1, Kathryn V Anderson

  • 1Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.

Annual Review of Cell and Developmental Biology
|May 18, 2007
PubMed
Summary
This summary is machine-generated.

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The primary cilium, a cellular organelle, is crucial for the Hedgehog (Hh) signaling pathway in mammals. This organelle organizes Hh signal transduction and is vital for vertebrate developmental signaling.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Molecular Biology

Background:

  • The primary cilium is a conserved organelle involved in cellular signaling.
  • Recent research highlights a significant link between the Hedgehog (Hh) pathway and primary cilia in mammals.

Purpose of the Study:

  • To investigate the role of primary cilia in mammalian Hedgehog (Hh) signal transduction.
  • To explore the involvement of cilia in other developmental signaling pathways.

Main Methods:

  • Analysis of mouse mutants affecting ciliary proteins.
  • Examination of Hh pathway components within primary cilia.
  • Investigation of PDGF receptor alpha signaling in fibroblasts.
  • Assessment of Wnt signaling in relation to cilia.

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Main Results:

  • Intraflagellar transport proteins essential for cilia are required for Hh pathway responses.
  • Hh signal transduction proteins are concentrated in primary cilia.
  • Cilia appear to function as machines organizing Hh signal transduction steps.
  • Cilia are necessary for PDGF receptor alpha signaling and potentially other vertebrate developmental pathways.
  • Cilia are not essential for Wnt signaling, but some interactions exist.

Conclusions:

  • Primary cilia play a critical, uniquely vertebrate role in organizing developmental signaling pathways, particularly the Hh pathway.
  • The function of cilia in developmental signaling is likely a vertebrate-specific phenomenon due to their widespread presence in vertebrate cells compared to invertebrates.