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Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
Published on: April 28, 2019
Study on reaction kinetics of synthesis of thioether by a visualization technique
Jin-Fang Chen1, Fang-Feng Hu, Jun-Hui Xu
1School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Hubei Key Laboratory of Novel Reactor & Green Chemical Technology, Wuhan 430073, PR China.
Abstract:
In this paper, a novel technique combined light-electronic microscopy and computer imaging trace was used to investigate the synthesis of thioether, which is an intermediate for lansoprazole. The reaction kinetics study by a visualization technique was carried out in a minireactor, and the concentration-grayscale standard curves for thioether were obtained by analyzing the grayscales of digital images for the solutions with 20 different concentrations. Based on the concentration-grayscale standard curves, the reactant concentrations at different times were calculated and the reaction kinetic curve as well as the reaction rate equation were obtained. It was found that the total mass-transfer resistance of sodium imidazole was larger than that of bromopyridine. Liquid-liquid interface of synthesizing thioether was observed and its mass transfer mechanism was discussed.
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