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Development and in vitro evaluation of buccoadhesive carvedilol tablets
Vamshi Vishnu Yamsani1, Ramesh Gannu, Chandrasekhar Kolli
1Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009, A.P. India.
Acta Pharmaceutica (Zagreb, Croatia)
|May 18, 2007
Summary
Buccoadhesive tablets of carvedilol were successfully developed using HPMC and Carbopol polymers. Formulation BC3 demonstrated optimal drug release and permeation through buccal mucosa, indicating potential for effective drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Carvedilol is an effective antihypertensive drug.
- Buccoadhesive drug delivery offers potential for improved bioavailability and sustained release.
Purpose of the Study:
- To develop and characterize buccoadhesive tablets of carvedilol.
- To evaluate the mucoadhesive properties, drug release, and permeation of carvedilol buccal tablets.
Main Methods:
- Buccoadhesive tablets were formulated using hydroxypropyl methylcellulose (HPMC K4M, HPMC K15M) and Carbopol 934 at various concentrations.
- In vitro drug release, bioadhesion, moisture absorption, and permeation studies through porcine buccal mucosa were conducted.
- Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD) were used for characterization.
Main Results:
- Formulation BC3 exhibited the highest drug release (88.7%) following the Higuchi model.
- BC3 showed significant drug permeation (21.5%) with a flux of 8.35 µg/h/cm², and favorable bioadhesion properties (peak detachment force 1.62 N).
- FTIR and XRD analyses confirmed no drug-polymer interactions and the crystalline state of carvedilol.
Conclusions:
- The study successfully developed carvedilol buccoadhesive tablets with desirable mucoadhesive and drug release characteristics.
- These tablets show promise for effective buccal drug delivery, enhancing carvedilol's therapeutic potential.
- The choice of mucoadhesive polymers significantly influences the performance of carvedilol buccal tablets.
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