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Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
Published on: November 2, 2018
Ocular drug delivery: molecules, cells, and genes
Xuyang Liu1, Curtis R Brandt, Carol A Rasmussen
1Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53705-3611, USA.
Summary
New molecular and cell biology advances offer novel gene therapies for ocular disorders. This review covers delivery systems, discussing their benefits and drawbacks for safe, long-term treatments.
Area of Science:
- Molecular Cell Biology
- Ophthalmology
- Biotechnology
Background:
- Ocular disorders represent a significant health burden.
- Traditional treatments for eye diseases have limitations.
- Advances in molecular cell biology offer new therapeutic avenues.
Purpose of the Study:
- To review the current state of delivery systems for ocular therapies.
- To focus on the application of gene therapy in ophthalmology.
- To discuss the advantages and limitations of various therapeutic and delivery methods.
Main Methods:
- Literature review of recent advances in molecular cell biology.
- Analysis of different delivery systems for ocular applications.
- Evaluation of gene therapy strategies for eye disorders.
Main Results:
- Several novel delivery systems are under development for ocular gene therapy.
- These systems aim to achieve safe and long-lasting therapeutic effects.
- Both advantages and limitations of current approaches are identified.
Conclusions:
- Delivery systems are crucial for the success of molecular and gene therapies in ophthalmology.
- Further research is needed to optimize these systems for clinical application.
- Gene therapy holds significant promise for treating a range of ocular disorders.
