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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Imaging diagnosis--canine thoracic mesothelioma
Rita L Echandi1, Federica Morandi, Shelley J Newman
1Department of Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine (UT-CVM), Knoxville, TN 37996, USA.
Mesothelioma, a rare cancer, can affect dogs, presenting as progressive cough and lung abnormalities. Early detection through imaging is crucial for diagnosis and treatment of this pleural tumor.
Area of Science:
- Veterinary Oncology
- Comparative Pathology
Background:
- Mesothelioma is a rare but aggressive neoplasm arising from mesothelial cells.
- Pleural mesothelioma can present with vague clinical signs in canine patients.
Observation:
- A Pembroke Welsh Corgi presented with a chronic, non-responsive productive cough.
- Thoracic imaging revealed pleural effusion, lung lobe collapse, and subpleural nodules.
Findings:
- Histopathologic examination confirmed the pleural nodules as mesothelioma.
- This case highlights the diagnostic challenges of canine mesothelioma.
Implications:
- Mesothelioma should be a differential diagnosis for dogs with unexplained pleural masses or persistent respiratory signs.
- Advanced imaging like computed tomography (CT) is vital for identifying and characterizing pleural lesions.
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