Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Associations of a facility level decrease in dialysate sodium concentration with blood pressure and interdialytic

Hla Thein1, Imad Haloob, Mark R Marshall

  • 1Department of Renal Medicine, Whangarei Hospital, Auckland, New Zealand.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|May 19, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocol for the 'exploration of mental well-being, health-related quality of life, and psychosocial outcomes in youths on dialysis in New Zealand: A cross-sectional methods study'.

PloS one·2026
Same author

Participant Perceptions of Increasing Water Intake in Polycystic Kidney Disease.

Kidney international reports·2025
Same author

Clinical study report data did not substantially alter point estimates but improved precision in a nephrology systematic review.

Journal of clinical epidemiology·2025
Same author

Safety, efficacy, and immunogenicity of a novel IgG degrading enzyme (KJ103): results from two randomised, blinded, phase 1 clinical trials.

Gene therapy·2025
Same author

Low dialysate sodium levels for chronic haemodialysis.

The Cochrane database of systematic reviews·2024
Same author

Long-term effect of increasing water intake on repeated self-assessed health-related quality of life (HRQoL) in autosomal dominant polycystic kidney disease.

Clinical kidney journal·2024
Same journal

Evidence-Based Medicine versus Personalized Medicine when attempting to block complement in IgA nephropathy.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Impact of immunosuppressive therapy on renal and patient survival in rapidly progressive secondary IgA nephropathy.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Severe Pregnancy-Associated Acute Kidney Injury and Maternal Vulnerability.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Correction to: Hyponatraemia-treatment standard 2024.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Effect of Semaglutide on Measured vs Estimated Glomerular Filtration Rate.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Beyond Diffusion and Convection: Is Adsorption the Third Dimension of Dialysis?

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
See all related articles

Lowering dialysate sodium concentration in hemodialysis patients safely reduced blood pressure. This intervention improved hypertension control without affecting interdialytic weight gain, suggesting volume-independent effects of sodium.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Hypertension

Background:

  • Dialysate sodium concentration is a potential, yet often overlooked, factor in hemodialysis-induced hypertension.
  • Hypertension remains a significant comorbidity in patients undergoing hemodialysis (HD).

Purpose of the Study:

  • To evaluate the impact of a facility-level reduction in dialysate sodium concentration on blood pressure and other clinical outcomes in hemodialysis patients.
  • To assess the safety and tolerability of decreased dialysate sodium levels.

Main Methods:

  • Observational study of 52 hemodialysis patients over 8 months, comparing outcomes before and after a dialysate sodium decrease from 141 to 138 mmol/l.
  • Utilized a longitudinal unbalanced panel design with hierarchical linear and Poisson mixed models to analyze blood pressure, interdialytic weight gain, and plasma sodium levels.

Related Experiment Videos

  • Patient demographics, clinical characteristics, and antihypertensive medication use were considered as covariates.

    • Main Results:

    • A statistically significant decrease in both systolic and diastolic blood pressure was observed post-intervention.
    • Pre-dialysis plasma sodium levels also decreased, while interdialytic weight gain remained unchanged.
    • The greatest blood pressure reduction was noted in patients with the highest initial blood pressure; no increase in adverse events occurred.

    Conclusions:

    • Reducing dialysate sodium concentration from 141 to 138 mmol/l is a safe and effective method for improving blood pressure control in hemodialysis patients.
    • The lack of change in interdialytic weight gain suggests that the blood pressure effects may be volume-independent, highlighting the role of sodium in hypertension beyond fluid balance.
    • This intervention offers a practical approach to managing hypertension in the hemodialysis population.