Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Coagulation

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...

Coagulation

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...

Fetal Circulation

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fathers' experiences of supporting their partners during their preterm infant's stay in the neonatal intensive care unit: a multi-method study.

Journal of perinatology : official journal of the California Perinatal Association·2021

Same author

Causes of Preanalytical Interferences on Laboratory Immunoassays - A Critical Review.

EJIFCC·2020

Same author

Sample management for clinical biochemistry assays: Are serum and plasma interchangeable specimens?

Critical reviews in clinical laboratory sciences·2018

Same author

Fathers' experiences with their preterm babies admitted to neonatal intensive care unit: A multi-method study.

Journal of advanced nursing·2018

Same author

Robotic assisted radical prostatectomy accelerates postoperative stress recovery: Final results of a contemporary prospective study assessing pathophysiology of cortisol peri-operative kinetics in prostate cancer surgery.

Asian journal of urology·2017

Same author

Preanalytical Nonconformity Management Regarding Primary Tube Mixing in Brazil.

Journal of medical biochemistry·2017

Search research articles

Related Experiment Video

Updated: Jul 14, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Routine coagulation tests in newborn and young infants.

Giuseppe Lippi¹, Gian Luca Salvagno, Simone Rugolotto

¹Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Ospedale Policlinico G.B. Rossi, Università degli Studi di Verona, Piazzale Scuro, 10, 37134 Verona, Italy. ulippi@tin.it

Journal of Thrombosis and Thrombolysis

|May 19, 2007

Summary

Interpreting coagulation tests in newborns requires age-specific reference ranges. Adult ranges for prothrombin time (PT) and activated partial thromboplastin time (APTT) are not suitable for infants, impacting diagnosis of haemostatic defects.

More Related Videos

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Related Experiment Videos

Last Updated: Jul 14, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Area of Science:

Neonatal Medicine
Hematology
Pediatric Coagulation

Background:

Diagnosing haemostatic defects in newborns is complex.
Coagulation test interpretation must consider age-dependent reference values.

Purpose of the Study:

To investigate the postnatal development of the human coagulation system in neonates.
To establish age-appropriate reference ranges for PT, APTT, and FBG in newborns.

Main Methods:

Prospective study of coagulation parameters in newborns.
Measurement of prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen (FBG) at birth and during the early postnatal period.

Main Results:

Fibrinogen (FBG) levels were within adult ranges at birth.
Prothrombin time (PT) normalized to adult ranges by 4 days postnatal.
Activated partial thromboplastin time (APTT) remained elevated above adult ranges up to 20 days postnatal.

Conclusions:

Adult reference ranges for PT and APTT are inappropriate for newborns and young infants.
Age-specific reference values are crucial for accurate interpretation of neonatal coagulation tests.