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Updated: Jul 14, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
Published on: February 15, 2016
Medicinal studies of dimeric phenols with multiple quaternary-ammonium pendant arms
Tian Tian1, Xiao-Cheng Weng, Yang Song
1College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.
Abstract:
A series of biphenol-derived quaternary ammonium salts, originally developed as DNA-cross-linking agents, and carrying either two (i.e., 1) or four (i.e., 2) net positive charges, were investigated for their in vitro DNA-transcription- and acetylcholinesterase (AChE)-inhibitory activities. The effects of charge and type of linker between the two phenolic residues were systematically investigated. Several compounds showed good activities in both tests, which makes them potential lead candidates for drug design.
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