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Related Experiment Video

Updated: Jul 14, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Anaplastic Large Cell Lymphoma.

L Jeffrey Medeiros1, Kojo S J Elenitoba-Johnson

  • 1Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4095, USA.

American Journal of Clinical Pathology
|May 22, 2007
PubMed
Summary

Anaplastic large cell lymphoma (ALCL) subtypes were discussed, focusing on anaplastic lymphoma kinase (ALK)+ ALCL and the diagnostic challenges of ALK- ALCL. Consensus criteria for ALK- ALCL are lacking, with debate on its distinct entity status.

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Area of Science:

  • Hematopathology
  • Oncology
  • Lymphoma Research

Background:

  • The 2005 Society of Hematopathology/European Association for Haematopathology Workshop addressed anaplastic large cell lymphoma (ALCL).
  • Focus was on anaplastic lymphoma kinase (ALK)+ ALCL and ALK- ALCL cases.
  • ALK- ALCL showed immunohistochemical overlap with classical Hodgkin lymphoma.

Purpose of the Study:

  • To review and discuss diverse cases of ALK+ and ALK- ALCL presented at the workshop.
  • To highlight diagnostic challenges, including immunohistochemical criteria and entity status for ALK- ALCL.
  • To explore the differential diagnosis of CD30+ anaplastic lymphomas involving the skin.

Main Methods:

  • Review of submitted cases of ALK+ and ALK- ALCL.
  • Discussion of clinical settings, histologic variants, and translocation partners.
  • Analysis of immunohistochemical profiles, including CD15 and CD30 expression.
  • Consideration of differential diagnoses for cutaneous lymphomas.

Main Results:

  • ALK+ ALCL cases presented unusual clinical and histologic features.
  • Significant immunohistochemical overlap between ALK- ALCL and classical Hodgkin lymphoma was observed.
  • Lack of consensus on histologic and immunohistochemical criteria for ALK- ALCL diagnosis was evident.
  • Debate exists on whether ALK- ALCL is a distinct entity or should be classified as peripheral T-cell lymphoma (PTCL), unspecified.

Conclusions:

  • Diagnostic criteria for ALK- ALCL require further refinement and consensus.
  • The distinctiveness of ALK- ALCL as an entity remains debated, with some advocating for its classification as PTCL, unspecified.
  • Differential diagnosis for cutaneous CD30+ lymphomas must include both cutaneous ALCL and systemic ALK- ALCL.

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Last Updated: Jul 14, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024