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A completely implantable total artificial heart system.

A Snyder1, G Rosenberg, W Weiss

  • 1Pennsylvania State University, Hershey.

ASAIO Transactions
|July 11, 1991
PubMed
Summary
This summary is machine-generated.

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Researchers tested a fully implanted total artificial heart (TAH) system in calves. The TAH system successfully maintained adequate cardiac output and safe pressures, demonstrating its potential for long-term use.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Surgery
  • Medical Devices

Background:

  • Congenital heart defects and end-stage heart failure necessitate advanced circulatory support.
  • Total artificial heart (TAH) systems offer a potential solution for patients awaiting heart transplantation or as a destination therapy.

Purpose of the Study:

  • To develop and evaluate a completely implanted total artificial heart (TAH) system for in vivo testing.
  • To assess the feasibility and performance of a novel TAH design in a large animal model.

Main Methods:

  • Development of a miniaturized roller screw energy converter and sac blood pumps.
  • Intrathoracic implantation of the motor drive, pumps, and compliance chamber.
  • Abdominal implantation of control electronics and battery, with transcutaneous energy transmission.

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Main Results:

  • Successful implantation and short-term survival (0.5-13 days) in three calves.
  • Consistent maintenance of safe left atrial pressures throughout the study period.
  • Adequate cardiac outputs were achieved, supporting vital physiological functions.

Conclusions:

  • The completely implanted TAH system demonstrated short-term in vivo efficacy in a large animal model.
  • The device successfully supported hemodynamic function, indicating promise for future development.
  • Further research is warranted to optimize the system for long-term implantation and clinical application.