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Related Experiment Videos

Drugs and the elderly patient.

Samer A Bsoul1, Geza Terezhalmy

  • 1Department of Dental Diagnostic Science, University of Texas Health Science Center, San Antonio Dental School, USA.

General Dentistry
|May 22, 2007
PubMed
Summary
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Polypharmacy in older adults increases adverse drug events due to age-related physiological changes. Careful drug selection and titration to clinical response are essential for safe medication use in the elderly.

Area of Science:

  • Geriatric Medicine
  • Clinical Pharmacology
  • Dental Practice

Background:

  • Older adults frequently have multiple chronic illnesses, leading to high prescription and over-the-counter (OTC) medication use.
  • Age-related physiological changes impact drug pharmacokinetics and pharmacodynamics, making extrapolation from younger populations unreliable.
  • Interindividual variability in the elderly complicates defining optimal therapeutic drug concentrations.

Purpose of the Study:

  • To highlight the challenges of rational drug use in older persons.
  • To emphasize the increased risk of adverse drug events in the elderly population.
  • To provide guidance on medication management for older adults, particularly for dental practitioners.

Main Methods:

  • Review of existing literature on geriatric pharmacotherapy.

Related Experiment Videos

  • Analysis of factors contributing to adverse drug events in the elderly.
  • Discussion of age-specific considerations in drug pharmacokinetics and pharmacodynamics.

    • Main Results:

    • Multiple chronic illnesses and OTC medication use contribute to a high incidence of adverse drug events in older adults.
    • Physiological changes with aging alter drug metabolism and response, necessitating cautious prescribing.
    • Poor nutrition and compliance can exacerbate medication-related problems.

    Conclusions:

    • Medications should be administered to elderly patients only when strictly necessary.
    • Dosages require careful titration based on clearly defined clinical responses.
    • Dentists should avoid prescribing drugs known to pose risks for older adults.