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Updated: Jul 14, 2026
07:33
Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
Published on: December 21, 2011
VEGF signaling through NADPH oxidase-derived ROS.
1Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago, Illinois 60612, USA. mfukai@uic.edu
Antioxidants & Redox Signaling
|May 22, 2007
Summary
Reactive oxygen species (ROS) generated by NADPH oxidase are crucial for vascular endothelial growth factor (VEGF)-mediated angiogenesis. Understanding these ROS-dependent signaling pathways in endothelial cells can lead to new therapeutic strategies for blood vessel formation.
Area of Science:
- Cell Biology
- Biochemistry
- Physiology
Background:
- Angiogenesis is vital for development, repair, and diseases like atherosclerosis.
- Vascular endothelial growth factor (VEGF) signaling via VEGFR2 drives endothelial cell (EC) proliferation and migration.
- Reactive oxygen species (ROS) act as signaling molecules in biological responses.
Purpose of the Study:
- To review the role of NADPH oxidase-derived ROS in angiogenesis.
- To explore regulators of ROS generation in VEGF signaling within ECs.
- To highlight the importance of subcellular localization for ROS-dependent signaling.
Main Methods:
- Literature review focusing on NADPH oxidase, ROS, and VEGF signaling.
- Analysis of mechanisms controlling ROS production in endothelial cells.
- Examination of subcellular compartments involved in redox signaling.
Main Results:
- VEGF stimulates ROS production through gp91phox (Nox2)-based NADPH oxidase in ECs.
- ROS are integral to VEGFR2-mediated EC migration and proliferation.
- NADPH oxidase-derived ROS are essential for postnatal angiogenesis.
- Specific subcellular localization of NADPH oxidase regulates ROS-dependent VEGF signaling.
Conclusions:
- NADPH oxidase-derived ROS play a critical role in angiogenesis.
- Regulators controlling ROS generation at specific subcellular sites are key for VEGF signaling.
- Targeting these mechanisms offers potential for therapeutic modulation of blood vessel formation.
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