Related Experiment Video
Updated: Jun 26, 2026
Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
Published on: July 28, 2016
Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction
Tessa J Mocatta1, Anna P Pilbrow, Vicky A Cameron
1Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand.
Objectives:
This study investigated relationships between plasma myeloperoxidase (MPO), protein oxidation markers, and clinical outcome retrospectively in patients after acute myocardial infarction (MI).
Background:
Reactive oxidants are implicated in cardiovascular disease, and elevated plasma MPO is reported to predict adverse outcome in acute coronary syndromes.
Methods:
Detailed demographic information, radionuclide ventriculography, neurohormone measurements, and clinical history were obtained for 512 acute MI patients at hospital admission. Plasma levels of MPO and protein carbonyls were measured in patients and 156 heart-healthy control subjects. 3-chlorotyrosine was measured in selected patients. Patient mortality was followed for 5 years.
Results:
Plasma MPO and protein carbonyl concentrations were higher in MI patients 24 h to 96 h after admission than in control subjects (medians: MPO 55 ng/ml vs. 39 ng/ml, and protein carbonyls 48 pmol/mg vs. 17 pmol/mg protein, p < 0.001 for each). Both markers were significantly correlated with each other and with cardiovascular hormone levels. Chlorotyrosine was not elevated in patients with high MPO or carbonyl levels. Above-median levels of MPO but not protein carbonyls were independently predictive of mortality (odds ratio 1.8, 95% confidence interval 1.0 to 3.0, p = 0.034). Patients with above-median MPO levels in combination with above-median plasma amino-terminal pro-brain natriuretic peptide (NT-proBNP) or below-median left ventricular ejection fraction (LVEF) had significantly greater mortality compared with other patients.
Conclusions:
Myeloperoxidase and protein carbonyl levels are elevated in plasma after acute MI, apparently via independent mechanisms. High MPO is a risk factor for long-term mortality and adds prognostic value to LVEF and plasma NT-proBNP measurements.
Insights
Elevated plasma myeloperoxidase (MPO) and protein carbonyls are found after acute myocardial infarction (MI). High MPO levels independently predict long-term mortality, adding value to existing prognostic markers.
Area of Science:
- Cardiovascular Medicine
- Biomarker Research
- Oxidative Stress
Background:
- Reactive oxidants play a role in cardiovascular disease.
- Elevated plasma myeloperoxidase (MPO) predicts adverse outcomes in acute coronary syndromes.
Purpose of the Study:
- To investigate the relationship between plasma MPO, protein oxidation markers, and clinical outcomes in acute myocardial infarction (MI) patients.
- To assess MPO and protein carbonyls as potential prognostic indicators post-MI.
Main Methods:
- Retrospective analysis of 512 acute MI patients and 156 controls.
- Measurement of plasma MPO, protein carbonyls, and 3-chlorotyrosine.
- 5-year mortality follow-up.
Main Results:
- MI patients showed higher plasma MPO and protein carbonyls compared to controls.
- MPO levels, but not protein carbonyls, independently predicted 5-year mortality.
- High MPO combined with low LVEF or high NT-proBNP indicated greater mortality risk.
Conclusions:
- Plasma MPO and protein carbonyls are elevated post-MI via independent mechanisms.
- High MPO is a significant risk factor for long-term mortality after MI.
- MPO provides added prognostic value to LVEF and NT-proBNP.
More Related Videos
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
07:25Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
