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Gamma-linolenate reduces weight regain in formerly obese humans
Marie A Schirmer1, Stephen D Phinney
1Department of Nutrition, University of California, Davis, CA 95616, USA.
The Journal of Nutrition
|May 22, 2007
Summary
Gamma-linolenate (GLA) supplementation significantly reduced weight regain in formerly obese individuals after major weight loss. This essential fatty acid may play a role in managing obesity by influencing fuel partitioning.
Area of Science:
- Nutrition Science
- Obesity Research
- Metabolic Studies
Background:
- Obesity is a major public health concern, with weight regain after loss being a significant challenge.
- Understanding the metabolic factors influencing weight regain is crucial for developing effective long-term weight management strategies.
Purpose of the Study:
- To investigate the effect of gamma-linolenate (GLA) supplementation on suppressing weight regain in formerly obese humans.
- To determine if GLA influences body composition and adipose tissue fatty acid profiles.
Main Methods:
- A double-blind, randomized study involving 50 formerly obese participants.
- Supplementation with 890 mg/d of GLA (from borage oil) or a placebo (olive oil) for 1 year.
- Assessment of body weight, composition, and adipose fatty acids at multiple time points (0, 3, 12, and 33 months).
Main Results:
- GLA supplementation significantly reduced weight regain compared to controls after 1 year (2.17 kg vs. 8.78 kg, P < 0.03).
- This effect was observed in subjects completing at least 50 weeks of supplementation.
- Adipose triglyceride GLA levels increased significantly (152%) in the GLA group after 12 months.
Conclusions:
- Gamma-linolenate (GLA) supplementation effectively reduces weight regain in humans following significant weight loss.
- Essential fatty acids, like GLA, may play a role in regulating fuel partitioning and preventing obesity.
- Further research into GLA's mechanisms in energy metabolism is warranted.
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