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Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

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Related Experiment Video

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Human osteoblast-like cells response to nanofunctionalized surfaces for tissue engineering.

Federico Caneva Soumetz1, Laura Pastorino, Carmelina Ruggiero

  • 1Department of Communication, Computer and System Sciences, University of Genova, Via Opera Pia, 13-16145 Genova, Italy. fedecnv@dist.unige.it

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|May 22, 2007
PubMed
Summary

This study developed biomimetic coatings using layer-by-layer assembly for bone-tissue engineering. These nanostructured ultrathin films effectively promote osteoblast-like cell proliferation on biomaterials.

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Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

Area of Science:

  • Biomaterials Science
  • Surface Engineering
  • Tissue Engineering

Background:

  • Cellular response is influenced by micro/nanotopographic and chemical surface features.
  • Engineering biomaterial surfaces is crucial for developing bioactive devices that elicit specific cellular responses.
  • The layer-by-layer (LBL) self-assembly technique offers a versatile method for modifying surface properties with ultrathin films.

Purpose of the Study:

  • To create biomimetic coatings containing fibronectin using LBL self-assembly.
  • To evaluate the potential of these coatings for bone-tissue engineering applications.
  • To assess the growth of MG63 human osteoblast-like cells on modified surfaces.

Main Methods:

  • Layer-by-layer (LBL) self-assembly technique was employed to create biomimetic coatings.
  • Quartz crystal microbalance (QCM) was used to optimize the assembly process.
  • Coatings were applied to nickel/titanium, silicon, and glass substrates for cell culture experiments.

Main Results:

  • Optimized LBL assembly process for fibronectin-containing coatings.
  • Successfully deposited nanostructured ultrathin films on various substrates.
  • Demonstrated enhanced MG63 cell proliferation on the modified surfaces.

Conclusions:

  • The developed nanostructured ultrathin films are effective in promoting cell proliferation.
  • The biomimetic coatings show high potential for engineering implants in bone-tissue engineering.
  • These coatings can optimize the integration of implants with surrounding tissues.