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Paired exchange programmes can expand the live kidney donor pool.

A O Mahendran1, P S Veitch

  • 1Renal Transplantation Unit, Royal Free Hospital and University College London Medical School, Pond Street, London NW3 2QG, UK.

The British Journal of Surgery
|May 22, 2007
PubMed
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Kidney paired donation (KPD) facilitates transplants between incompatible donor-recipient pairs, increasing organ availability. Addressing ethical and logistical challenges is key to expanding this life-saving strategy.

Area of Science:

  • Nephrology
  • Transplantation immunology
  • Organ donation policy

Background:

  • Kidney paired donation (KPD) involves exchanging organs between incompatible live donor-recipient pairs.
  • KPD aims to improve recipient quality of life and longevity through compatible transplants.

Purpose of the Study:

  • To review the literature on kidney paired donation (KPD).
  • To identify protocols, policies, and barriers associated with KPD programs.

Main Methods:

  • Systematic literature search of Medline using relevant keywords.
  • Identification and analysis of publications on KPD protocols, policy, modeling, ethics, and logistics.

Main Results:

  • KPD increases transplantation rates for incompatible donor-recipient pairs.

Related Experiment Videos

  • Ethical issues include confidentiality, conditionality, synchronicity, and potential disadvantage to blood group O recipients.
  • Logistical barriers involve donor surgery location and organ transport.

    • Conclusions:

    • KPD expands the living donor pool, offering a viable strategy for incompatible pairs.
    • Widespread KPD implementation requires resolution of ethical and logistical constraints.